Studying the anticancer activity in vitro of doxorubicin-encapsulated pH-sensitive redox nanoparticles

Doxorubicin (DOX) is known as a chemotherapeutic agent for treating variety of cancers. However, due to non-specific distribution, DOX causes severe side effects, leading the limitation its clinical application. In this study, pH-sensitive redox nanoparticles containing were studied form drug-coated with size about 40-60 nm that increases concentration drugs accumulated at tumor site in response low pH conditions. The optimal properties investigated by analysing antioxidant activity, sensitivity pH, drug delivery environment, and toxicity on cancer cells, thereby observing possibility inhibiting migration cells. Results showed combination not only anticancer colorectal (C-26), breast (MCF-7) but also reduces bovine aorta endothelial cells (BAEC) inhibits C-26 cell vitro.Thepaper results reveal application potential improving effectiveness treatment.